Preventing Asthma in High Risk Kids

Exclusion Criteria

• •1. \>4 episodes of wheezing in the past year
• •2. Use of Step 5 or Step 6 therapy (ICS plus LABA ) at the time of enrollment (Visit 0).
• •3. Need for systemic corticosteroids or a hospitalization for respiratory symptoms within four weeks prior to screening.
• •4. Three or more courses of systemic corticosteroids for wheezing illnesses in the last year
• •5. More than four days of symptoms of wheezing, or tightness in the chest or cough in the past two weeks causing at least minimal limitation of activity
• •6. More than four days of albuterol treatment (for symptoms) in the past two weeks
• •7. More than one night of symptoms of wheezing, or tightness in the chest or cough causing sleep disruption in the past two weeks
• •8. More than one night of albuterol treatment (for symptoms) in the past two weeks
• •9. Prematurity (\<34 weeks gestation)
• •10. Need for oxygen for more than 5 days in the neonatal period
• •11. History of intubation or mechanical ventilation for respiratory illness
• •12. Other significant medical conditions, including: major congenital anomalies, cystic fibrosis, chronic pulmonary diseases, bronchopulmonary dysplasia, thoracic surgery, history of tuberculosis, immunodeficiency (primary or secondary), seizure disorders
• •13. Expecting to relocate within 4 years of study initiation to a place which would make in-person clinical visits impossible
• •14. Deemed unable to adhere to study activities
• •15. Prior aeroallergen immunotherapy or use of biologics including anti-IgE
• •16. Prior IVIG or systemic immunosuppressant other than corticosteroids
• •17. History of hypoxic seizures during a wheezing episode
• •18. Total IgE outside of the omalizumab dosing range.
• •19. Enrolled in any clinical medication trial within the past 30 days.
• •20. With platelet counts \< 150 x 109/L at the Screening Visit (V0)
• •21. Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or may impact the quality or interpretation of the data obtained from the study.
• •22. History of severe anaphylactic/anaphylactoid reactions from any cause