Lead Sponsor

Universiteit Antwerpen

Age

18 - 85 years

Sex

ALL

Healthy Volunteers

No

•Admitted to PZ Duffel and eligible for ECT because of major depressive disorder of major depressive episode in bipolar disorder (according to DSM-5 criteria).
•Score on HDRS ≥ 17.
•Have signed an IC form indicating that they understand the purpose of and procedures required for the study and are willing to participate in this study. In case of incapacity, a close relative will be asked to give informed consent.
•Be medically stable on the basis of physical examination and vital signs performed during the pre-ECT screening procedure.

•Drug or alcohol dependence as detected in the MINI interview at screening (\<6 months before ECT).
•Primary psychotic disorder according to DSM-5 criteria (\<6 months before ECT).
•Is currently enrolled in a study with an investigational study drug.
•Has any condition that, in the opinion of the investigator, would compromise the wellbeing of the subject or the study or prevent the subject from meeting or performing study requirements.