The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine

Inclusion Criteria

• •Adult patients
• •Singleton pregnancy
• •Patients with remaining hypertension despite an oral treatment for who an iv antihypertensive treatment is indicated
• •Patient with PE, as defined by :
• •Systolic Blood Pressure (BP) ≥ 140 mmHg and/or Diastolic BP ≥ 90 mmHg, after the 20th week of amenorrhea, without chronic hypertension, AND
• •Proteinuria \> 300 mg.day-1 or \> 2 crosses(++) on an urinary dipstick,
• •OR
• •Patient with severe Pregnancy Induced Hypertension (PIH), as defined by :
• •Systolic BP ≥ 160 mmHg and/or Diastolic BP ≥110 mmHg, after the 20th week of amenorrhea, without chronic hypertension,
• •Written informed consent signed and dated by both investigator and patient,
• •Valid social security affiliation