Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Strasbourg, France
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Adult patients
Singleton pregnancy
Patients with remaining hypertension despite an oral treatment for who an iv antihypertensive treatment is indicated
Patient with PE, as defined by :
Systolic Blood Pressure (BP) ≥ 140 mmHg and/or Diastolic BP ≥ 90 mmHg, after the 20th week of amenorrhea, without chronic hypertension, AND
Proteinuria \> 300 mg.day-1 or \> 2 crosses(++) on an urinary dipstick,
OR
Patient with severe Pregnancy Induced Hypertension (PIH), as defined by :
Systolic BP ≥ 160 mmHg and/or Diastolic BP ≥110 mmHg, after the 20th week of amenorrhea, without chronic hypertension,
Written informed consent signed and dated by both investigator and patient,
Valid social security affiliation
You may not be if
Known allergy to study drugs
Contra-indication to the study drugs: stenosis of the aortic isthmus, arteriovenous shunt, coarctation of the aorta, unstable angina, compensatory hypertension, myocardial infarction \< 8 days.
Eclampsia
Person with difficulty understanding information
Person with diminished responsibility,
Ongoing intravenous antihypertensive treatment,
No pressure cuff adapted to the morphology of the arms of the patients
Concomitant use of 5 phosphodiesterase inhibitors
Participation in a clinical trial within 6 months prior to inclusion
Clareo Health | The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
