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COMPLETEDPhase 3NCT02533648

Role of Allopurinol on Oxidative Stress and Mitochondrial Alterations in Skeletal Muscle of Diabetic Patients

Our recent data in mice have demonstrated a key role of xanthine oxidase in hyperglycemia-induced by Reactive oxygen species production, and a preventive role of allopurinol (inhibitor of xanthine oxi...

Lead sponsor: Hospices Civils de Lyon•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Hospices Civils de Lyon

Age

30 - 60 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•BMI from 25 to 40 kg/m²
•Type 2 diabetes known for over one year but less than 10 years, treated with Oral anti-diabetic drugs or a Glucagon-like peptide-1 (GLP1-analog)
•well controlled hypertension (untreated or currently treated) with a systolic blood pressure of 95 to 140 mmHg and diastolic blood pressure of 45 to 90 mmHg and heart frequency of 40 to 100 per minute
•Recent HbA1c \< 9 %
•Uricemia \> 300 µmol/l
•For women : Menopausal or contraception
•Renal function as defined by glomerular filtration rate (GFR) ≥ 80 mL/min/1.73 m2

Exclusion Criteria

•Tobacco ( more than 5 cigarettes)
•Excessive drinking
•Known pathology
•Hypersensitivity to allopurinol
•Treatment by anticoagulants, allopurinol, regular steroids or Nonsteroidal anti-inflammatory drug (NSAID), fibrate or insulin

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: November 1, 2019Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE3

Enrollment31

Start dateSep 2011

Last updatedNov 1, 2019

Condition

Type 2 Diabetes Mellitus

Locations shown

CRNH Rhône Alpes

Lyon

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 1, 2019Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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