Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ludwig-Maximilians - University of Munich
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Men and women 18-65 years of age.
Primary DSM-5 diagnosis of Major Depression as assessed by the Structured Clinical Interview for DSM-5 Axis I Disorders, Research Version (SCID-5-RV) with a single or recurrent episode with the additional requirements of a current episode with a duration of ≥4 weeks.
Current depressive episode is less than 5 years duration (the definition of an episode is demarcated by a period of ≥2 months in which the patient did not meet full criteria for the DSM-5 definition of major depressive episode).
Total HDRS-21 ≥15 at the screening visit.
The patient did not respond to at least one antidepressant treatment, i.e., a minimum of 1 and a maximum of 4 antidepressant drug trials, of adequate dose and duration (defined as a minimum level of 2 on the ATHF) in the current episode.
Patient is taking a SSRI of adequate dose and ≥4 weeks (defined as a minimum level of 2 on the ATHF) in the current episode.
Capable and willing to provide informed consent.
Negative pregnancy test and willingness to use contraceptive measures during study treatment for women with childbearing potential (i.e \<. 2 years post-menopausal)
You may not be if
Investigators, site personnel directly affiliated with this study, and their immediate families (immediate family is defined as a spouse, parent, child or sibling, whether by birth or legal adoption).
Acute risk for suicide (MADRS, item 10 score of \>4 or as assessed by the C-SSRS, agree to item 4 and/or to item 5).
High degree of therapy resistance defined as \>4 sufficient treatment attempts in the current episode (each attempt with an ATHF score of \>3).
Treatment with electroconvulsive therapy in the present episode.
Treatment with deep brain stimulation or vagus nerve stimulation and/or any other intracranial implants (clips, cochlear implants).
Any other relevant psychiatric axis-I- and/or axis-II-disorder.
Any relevant instable medical condition.
History of treatment with tDCS for any disorder.
Pregnancy.
Clareo Health | Transcranial Direct Current Stimulation (tDCS) As Treatment for Major Depression
