Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy)

Exclusion Criteria

• •1. Use of a PDE inhibitor in the past 30 days
• •2. History of a seizure disorder unrelated to hypocalcemia
• •3. History of a cardiac arrhythmia (not including bradycardia)
• •4. History of hepatic insufficiency
• •5. AST or ALT \>2x upper limit of normal
• •6. Total bilirubin \>1.5 x upper limit of normal (unless patient has a diagnosis of Gilbert's syndrome and no other causes leading to hyperbilirubinemia are identified)
• •7. Congestive heart failure
• •8. Cigarette use in the past 30 days
• •9. Alcohol use within the past 24 hours
• •10. Current pregnancy
• •11. Untreated hypothyroidism (defined as free T4 level \< 0.6 ng/dL or TSH \>10 mcU/mL)
• •12. Active peptic ulcer disease
• •13. Fever \>101 degrees in the past 24 hours
• •14. Current use of medications known to effect theophylline levels (listed below)
• •15. Severe sleep apnea requiring BiPAP
• •Drugs with clinically significant drug interactions with theophylline:
• •Allopurinol
• •Cimetidine
• •Ciprofloxacin
• •Clarithromycin
• •Enoxacin
• •Ephedrine
• •Erythromycin
• •Estrogen
• •Flurazepam
• •Fluvoxamine
• •Lithium
• •Lorazepam
• •Methotrexate
• •Midazolam
• •Pentoxifylline
• •Propranolol
• •Rifampin
• •Sulfinpyrazone
• •Tacrine
• •Thiabendazole
• •Ticlopidine
• •Troleandomycin
• •Verapamil