Effect of AT-derived miRNA on the Biology and Insulin Sensitivity of Skeletal Muscle in Humans

Exclusion Criteria

• •Lactation or pregnancy, current and/or within last 6 months, per participant's report
• •Female subjects postmenopausal
• •Cardiovascular disease (unstable angina, myocardial infarction or coronary revascularization within 6 months)
• •Liver disease (AST or ALT(alanine aminotransferase)\>2.5 times the upper limit of normal)
• •Kidney disease (creatinine \>1.6 mg/dl)
• •Anemia (hemoglobin \<12 g/dl in men, \<11 g/dl in women)
• •Thyroid dysfunction (abnormal TSH)
• •HbA1c ≥6.5%
• •Uncontrolled hypertension (systolic BP\>160 mmHg, diastolic BP\>100 mmHg)
• •History of coagulopathies
• •History (within the last 5 years) or presence of malignancy, (skin cancers, with the exception of melanoma, may be acceptable)
• •Current or history of drug abuse or alcohol abuse (\>2 drinks/day)
• •Prior treatment (within last 3 months) with systemic glucocorticoids (\>2 weeks), beta-blockers, drugs for weight loss, niacin or fibrates
• •History of HIV, active Hepatitis B or C, or Tuberculosis (participant reported)
• •Smoke \> 5 cigarettes per day