Effectiveness and Safety of Electro-acupuncture for Mild-to-moderate Perimenopausal Depression

Exclusion Criteria

• •Fail to rule out the possibility of suicide in depression factor of The Symptom Checklist (SCL-90);
• •Application of estrogen, progesterone, selective serotonin reuptake inhibitors (SSRIs), soybean isoflavone, vitamin E or black cohosh in recent 4 weeks;
• •Allergic to citalopram or escitalopram tablets;
• •Taken the non selective, irreversible inhibitor of monoamine oxidase (MAOIs) in recent 2 weeks;
• •Taken linezolid, pimozide, tryptophane,tramadol, triptans or other drugs that may cause drug adverse reactions in recent 2 weeks;
• •Patient with prolongation of the QT interval or congenital long QT syndrome
• •Taken herbs or products that contain isatin, pilose antler, hawthorn, fleeceflower root, common St.John's wort herb, hypericin;
• •Ovarian dropsy or hysteromyoma with more than 4cm diameter, oophorectomy, or hysterectomy;
• •Mandatory indications of hormonotherapy, such as surgery-induced menopause or osteoporosis;
• •Patient with history of radiotherapy or chemotherapy, or undergoing radiotherapy or chemotherapy;
• •Vaginal bleeding of undetermined origin;
• •Patient with coagulation disorders, or taking anticoagulants such as Warfarin, or heparin;
• •Patient with skin diseases, such as eczema,or psoriasis;
• •Serious hepatic insufficiency or serious renal inadequacy;
• •Uncontrolled hypertension, diabetes, or thyroid disease;
• •Diabetic neuropathy, or malignant tumor;
• •Pregnancy intention, in pregnancy or lactation;
• •Regular use of sedative and anti anxiety drugs;
• •The long-term smoking and/or drinking;
• •Having Pacemaker or artificial joint；
• •Electrolyte is disorder, serious heart disease or other potential life-threatening disease patients;
• •Compliance may be poor or fear of acupuncture.