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Lead
Isarna Therapeutics GmbH
The transforming growth factor beta (TGF-β) is known to play a key role in glaucoma. Increased levels of TGF-β2 in the eye have been linked to trabecular meshwork transformation, increased intraocular pressure and direct optic nerve damage.
Trabeculectomy is the standard surgical intervention to reduce intraocular pressure in subjects no longer sufficiently responding to pressure-lowering medications. Scarring of the surgically opened canal (bleb) often abolishes the effect of trabeculectomy (despite the intraoperative use of Mitomycin C to prevent this). TGF-β2 has been described to play a distinct role in the fibrotic process of bleb closure.
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subject scheduled for trabeculectomy with Mitomycin C
Subject no longer tolerating or benefitting from pharmacologic treatment of glaucoma
You may not be if
History of relevant ocular trauma \< 6 months or ocular infection/inflammation \< 3 months
severe central visual field loss within 6 months unrelated to glaucoma
pregnant or nursing women or subjects not using adequate contraception
history or evidence of any other clinically significant disorder, condition or disease that would pose a risk to subject safety or interfere with study evaluations, procedures or interpretation
