Induction Chemotherapy Followed by Chemoradiotherapy in Esophageal Cancer

Inclusion Criteria

• •1. Histologically confirmed squamous cell carcinoma of the esophagus;
• •2. Localized, nonmetastatic disease (T1-4, N0-1) confirmed by endoscopic ultrasound (EUS) and CT scan (according to UICC TNM version 6);
• •3. Absence of distant metastasis of solid organ;
• •4. Not suitable for surgery (either for medical reasons or patient's choice);
• •5. Age at diagnosis 18 to 70 years;
• •6. Eastern Cooperative Oncology Group performance status ≤ 2
• •7. No prior cancer therapy;
• •8. No history of concomitant or previous malignancy;
• •9. Hematologic function: WBC ≥ 4.0×109/L, PLT ≥ 80×109/L, Hb ≥ 10mg/dL;
• •10. Renal function: Cr ≤ 1.25×UNL;
• •11. Hepatic function: BIL ≤ 1.5×UNL, ALT/AST ≤ 2.5×UNL;
• •12. Documented informed consent to participate in the trial.