A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain

Inclusion Criteria

• •1. Subjects who provide written informed consent prior to enrollment.
• •2. Male or female and 18 years of age or older.
• •3. Subjects who are scheduled to undergo elective general surgery including, but not limited to the following surgical types:
• •* Abdominal surgery
• •* Orthopedic surgery
• •* Spine surgery
• •* Genitourinary surgery
• •4. Subjects classified as American Society of Anesthesiologists (ASA class I-III).
• •5. Female subjects are eligible only if all of the following apply:
• •* Not pregnant (subjects of child bearing potential must have a negative beta human chorionic gonadotropin (β-hCG) pregnancy test before surgery);
• •* Not lactating;
• •* Not planning to become pregnant within the duration of the study;
• •6. Subjects who are expected to have acute pain requiring oral opioid analgesics for at least 48 hours during the post operative period (either inpatient or outpatient).
• •7. Subjects who are willing and capable of understanding and cooperating with the requirements of the study.
• •8. Subjects able to understand and communicate in English.