Inflammation and Post-Stroke Depression

Inclusion Criteria

• •The subjects will be male and female patients with acute ischemic stroke of the brain. Vascular risk factors, including diabetes, hypertension, and coronary artery disease, are expected to be common, and will be recorded in the Source Documents (appendix). Patients will be included if:
• •* Aged ≥ 18 years of age
• •* Neuroimaging or clinical symptoms are consistent with an acute ischemic stroke (AIS)
• •* There are no alternative explanations for symptoms (eg. tumor, witnessed seizure, history of complicated migraine headache, hypoglycemia \[blood sugar (BS) \< 50 mg/dL\] or hyperglycemia (BS \> 400 mg/dL)
• •* Subject is able to be enrolled and have blood samples drawn (Note: inability to provide a sample within 48 hours does not preclude inclusion if consent is provided after this time and patient can provide blood at subsequent time points (see Table)
• •* Subject is able to provide informed consent for participation in this research study