The PK/PD, Efficacy, Safety and Tolerability Study of SHR3824 in Type 2 Diabetes Mellitus Patients

Exclusion Criteria

• •Type I diabetes mellitus, diabetes mellitus resulting from pancreatic disorder, or secondary diabetes mellitus (acromegaly, Cushing's syndrome, etc.);
• •Past or current history of severe diabetic complications (proliferative diabetic retinopathy, stage III or later stage overt nephropathy, diabetic ketoacidosis, or serious diabetic neuropathy);
• •Systolic blood pressure of ≥160 mmHg or diastolic blood pressure of ≥100 mmHg on the start or end day of the run-in period;
• •History of myocardial infarction, unstable angina, or cerebrovascular disorder within 6 months before the start of the run-in period;
• •Past or current history of malignant tumor;
• •Past or current history of drug hypersensitivity such as shock and anaphylactoid symptoms;
• •Pregnant women, lactating mothers, or women of childbearing potential;
• •Any condition that subjects are assessed to be ineligible by the investigator (sub investigator).