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Keep this study
Lead
Wake Forest University Health Sciences
With
National Cancer Institute (NCI)
PRIMARY OBJECTIVES:
I. To evaluate the hypothesis that there are more hyaluronan synthase 2 (HAS2)+ cells in patients with bone metastasis compared to patients with only local disease.
SECONDARY OBJECTIVES:
I. To evaluate the hypothesis that cells with HAS2+ and cancer stem cell (CSC)+ (cluster of differentiation \[CD\]24-/CD44+/epithelial specific antigen \[ESA\]+) cells will have the most aggressive growth in the bone, using an animal model.
OUTLINE:
Blood and bone marrow samples are collected and analyzed via flow cytometry and polymerase chain reaction (PCR). Cells are also transplanted into mice and studied.
Age
20–60
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Patients must have newly diagnosed, histologically confirmed primary and/or metastatic breast cancer
Ability to understand and the willingness to sign an Institutional Review Board (IRB)-approved informed consent document
You may not be if
Patients who have had chemotherapy or radiotherapy
Clareo Health | Role of Hyaluronic Acid in Causing Cancer Stem Cell Growth in the Bones of Patients With Breast Cancer
