Bendamustine Hydrochloride in Treating Patients With Previously Treated Multiple Myeloma

Inclusion Criteria

• •1. Patients with multiple myeloma who have not achieved a CR following at least 4 cycles of induction therapy
• •2. Age up to 80 years
• •3. ECOG Performance Status of 0 or 1
• •4. Left ventricular ejection fraction =/\> 40%. No uncontrolled arrhythmias or symptomatic cardiac disease
• •5. FEV1, FVC and DLCO =/\> 40%. No symptomatic pulmonary disease.
• •6. Serum bilirubin \<2 x upper limit of normal, alkaline phosphatase \<3 x upper limit of normal. No evidence of chronic active hepatitis or cirrhosis. No effusion or ascites \> 1 L prior to drainage.
• •7. HIV negative
• •8. Negative beta HCG test in woman with child bearing potential, defined as not post-menopausal for 12 months or no previous sterilization
• •9. Patients or guardian able to sign informed consent
• •10. Availability of previously collected autologous stem cells (at least 3.0 x 106 CD34 cells/kg)
• •11. Calculated GFR \> 50 ml/minute