Precapillary PAH: Wedge-pressure \<= 15 mmHg, CO normal or low
Postcapillary PAH: Wedge-pressure \>= 15 mmHg, CO normal or low
Diabetic nephropathy:
Diabetes mellitus Type 2 with oral or Insulin therapy and one or more of the following:
Diabetic nephropathy has been diagnosed before (anamnesis)
Macroalbuminuria: Urine Albumine/Creatinine-ratio \> 300mg/g Creatinine (\>34mg/mmol) in 2 out of 3 tests of Urine in the morning and GFR \<90ml/min/1.73m² (CKD-EPI)
Microalbuminuria: 30-300mg/g Creatinine (\>=3.4 mg/mmol but \<34mg/mmol) tested as above and GFR \< 90 ml/min/1.73m² and diabetic retinopathy
AH:
Hypertension diagnosed at least 6 months except structural heart disease: EF \> 55% and no sign of HFpEF
No symptoms of coronary heart disease
Possibility to take part in cardiac stress test
Stable pharmacologic therapy of Hypertension for at least 4 weeks
Systolic blood pressure \<140 mmHG during Screening
You may not be if
Patient incapable of contracting
Angina pectoris \> CCS II
Coronary Intervention in the last 4 weeks or scheduled Intervention/Bypass
Myocardial infarction in the last 3 months
Stroke in the last 3 months
Valvular heart disease \> II°
Cardiomyopathy due to Infiltrate/hypertrophic obstruction (e.g. HOCM, Amyloidosis)
Congenital complex heart disease
Active myocarditis
Significant lung disease
Significant Cardiac dysrhythmia
Scheduled changes in medication during time of study
(Scheduled) heart transplant
Cardiac resynchronisation therapy over the last three months
