Efficacy and Safety of Domestic Tenofovir Tablets in Chinese Patients With Chronic Hepatitis B

Inclusion Criteria

• •The initial treatment of subjects diagnosed of HBeAg positive or negative chronic hepatitis B
• •Aged 18 to 65 years old，male or female
• •Patients with previously HBsAg-positive lasted for 6months at least：HBeAg-positive subjects, HBV-DNA\> 105copies/ml； HBeAg-negative subjects, HBV-DNA\> 104copies/ml.
• •2 times the upper normal limit (2 × ULN) ≤ alanine aminotransferase (ALT) ≤ 10 × ULN.
• •Total serum bilirubin (TBIL) ≤ 2.5 × ULN.
• •Prothrombin activity (PTA) ≥ 60% or prothrombin time prolonged than normal ≤ 3 seconds).
• •WBC ≥ 3.5 × 109 / L, PLT ≥ 80 × 109 / L, serum albumin (ALB)≥ 35 g / L.
• •Creatinine (Cr) ≤ 1× ULN，serum phosphate was normal.
• •Patients signed an informed consent form and compliance was good.