Efficacy of Vortioxetine on Cognitive Dysfunction in Working Patients With Major Depressive Disorder

Exclusion Criteria

• •The patient has a score ≥70 on the DSST (number of correct symbols) at the Baseline Visit.
• •The patient is, in the opinion of the investigator, not able to complete the neuropsychological tests validly at the Baseline Visit.
• •The patient has physical, cognitive, or language impairment of such severity as to adversely affect the validity of the data derived from the neuropsychological tests.
• •The patient is diagnosed with reading disability (dyslexia).
• •The patient has a history of lack of response to previous adequate treatment with vortioxetine or paroxetine.
• •The patient has any current psychiatric disorder or Axis I disorder (according to DSM-IV-TR™ criteria) other than MDD, as assessed using MINI.
• •The patient has a current or has had a diagnosis of dysthymic disorder within 3 months preceding the onset of current episode (DSM-IV-TR™ criteria).
• •The patient has borderline, schizotypal, schizoid, paranoid, or histrionic, antisocial personality disorders (axis II) as comorbid or primary diagnosis (DSM-IV-TR™ criteria).
• •The patient suffers from personality disorders, mental retardation, pervasive development disorder, attention-deficit/hyperactivity disorder, organic mental disorders, or mental disorders due to a general medical condition (DSM-IV-TR™ criteria).
• •The patient has a current diagnosis or history of manic or hypomanic episode, schizophrenia or any other psychotic disorder, including major depression with psychotic features (DSM-IV-TR™ criteria).