Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment

Exclusion Criteria

• •Lifetime DSM 5 diagnosis of schizophrenia, bipolar disorder, or OCD
• •DSM 5 diagnosis of alcohol or other substance use disorder within the past 12 months
• •High risk for suicide
• •Significant neurological conditions (e.g. stroke, seizure disorder, MS)
• •Unstable medical illnesses (e.g. uncontrolled diabetes mellitus or hypertension)
• •Taking anticonvulsants or other psychotropic medication that may interfere with cognitive testing that cannot be safely tapered and discontinued
• •Current depressive symptoms defined as a MADRS score of 10 or above
• •Specific Eligibility Criteria for the MCI Group:
• •Inclusion:
• •Aged 60 or older
• •Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI")
• •Exclusion:
• •Having taken a cognitive enhancer within the past 6 weeks
• •Specific Eligibility Criteria for the rMDD Group:
• •Inclusion:
• •Aged 65 or older
• •Meets DSM 5 criteria for one or more major depressive episode(s) (MDE) during their adult life (i.e. 18 years of age or older) with: (a) an offset of 2 months to 5 years from the screening visit date, or (b) an offset of 5 years or more, with at least one MDE receiving medical attention (e.g. previously been on an antidepressant, saw a psychiatrist, primary care physician, or had a previous hospitalization
• •Exclusion:
• •Having taken a cognitive enhancer within the past 6 weeks
• •Having received electroconvulsive therapy (ECT) within 6 months of baseline neuropsychological testing
• •Specific Eligibility Criteria for the Control Group:
• •Inclusion:
• •Aged 60 or older
• •Exclusion:
• •Meets DSM 5 criteria for MDD at anytime during their lifetime
• •Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI")