Unstable medical illnesses (e.g. uncontrolled diabetes mellitus or hypertension)
Taking anticonvulsants or other psychotropic medication that may interfere with cognitive testing that cannot be safely tapered and discontinued
Current depressive symptoms defined as a MADRS score of 10 or above
Specific Eligibility Criteria for the MCI Group:
Inclusion:
Aged 60 or older
Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI")
Exclusion:
Having taken a cognitive enhancer within the past 6 weeks
Specific Eligibility Criteria for the rMDD Group:
Inclusion:
Aged 65 or older
Meets DSM 5 criteria for one or more major depressive episode(s) (MDE) during their adult life (i.e. 18 years of age or older) with: (a) an offset of 2 months to 5 years from the screening visit date, or (b) an offset of 5 years or more, with at least one MDE receiving medical attention (e.g. previously been on an antidepressant, saw a psychiatrist, primary care physician, or had a previous hospitalization
Exclusion:
Having taken a cognitive enhancer within the past 6 weeks
Having received electroconvulsive therapy (ECT) within 6 months of baseline neuropsychological testing
Specific Eligibility Criteria for the Control Group:
Inclusion:
Aged 60 or older
Exclusion:
Meets DSM 5 criteria for MDD at anytime during their lifetime
Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI")
Clareo Health | Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
