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Morbidity in Patients With Hypertension and Obstructive Sleep Apnea | Clinical Trials | Clareo Health

COMPLETEDNA

Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

NCT02270658•University of Sao Paulo General Hospital

Summary

MORPHEOS is a multicenter, randomized, unblinded study, for patients diagnosed with uncontrolled hypertension and at least one antihypertensive medication. Those patients with significant sleep apnea wil be randomized to CPAP or nasal strips for 6 months.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg
•Current treatment with at least 1 antihypertensive drug

Exclusion Criteria

•Age \<18 and \>65 years
•BMI ≥ 40 kg/m2
•Heart failure, EF \< 45%, acute myocardial infarction, stroke, significant valvular dysfunction
•Chronic renal failure (serum creatinine \> 2 mg/dL)
•Use of cocaine, amphetamines, alcohol, illicit drugs
•Use of sympathomimetics (decongestants, appetite suppressants)
•Use of oral contraceptives and chronic use of NSAIDs
•Pregnancy
•Secondary causes of hypertension (other than sleep apnea)

Locations (5)

Pronto Socorro Cardiológico de Pernambuco (PROCAPE)

Recife, Pernambuco, Brazil

Hospital das Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto

Ribeirão Preto, São Paulo, Brazil

Fundação Zerbini - Instituto do Coração (InCor)

São Paulo, São Paulo, Brazil

Hospital Universitário da Universidade de São Paulo (HU)

São Paulo, São Paulo, Brazil

Key Dates

Start Date

January 1, 2015

Primary Completion Date

January 1, 2020

Completion Date

December 1, 2020

Last Updated

September 28, 2023

Enrollment

123

ACTUAL participants

Conditions

HypertensionSleep Apnea, Obstructive

Interventions

CPAP

DEVICE

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RECRUITING

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 28, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

Inclusion Criteria

Exclusion Criteria

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