CKD-828 (80/5mg) Pharmacokinetic Study

Exclusion Criteria

• •History of relevant hypersensitivity against drug
• •Clinical significant disease or medical history (ex. hepato/cholangio, cardio, endo, hemato, onco, CNS etc.)
• •Active liver disease or abnormal laboratory result (AST or ALT or Total bilirubin \> 1.5\*ULN)
• •SBP \<90mmHg or SBP \>150mmHg
• •DBP \<50mmHg or DBP \>100mmHg
• •Creatinine clearance \<80mL/min
• •A Disease(ex.inflammatory intestinal disease, gastric or duodenal ulcer ,hepatic disease history , gastro-intestinal surgery except for appendectomy)that may influence on the absorption, distribution, metabolism and excretion of the drug
• •The evidence of severe attack or acute disease or surgical intervention within 28 days prior to the first IP administration.
• •A drug abuse or a heavy caffeine consumer (more than 5 cups per a day) or regular alcohol consumer(more than 21 units/week) or a heavy smoker(more than 10 cigarettes per a day)
• •Taking ETC medicine or oriental medicine within 14days or Taking OTC medicine within 7days prior to the first IP administration
• •Abnormal diet(Especially, grapefruit juice within 7 days prior to the first IP administration) that may influence on the absorption, distribution, metabolism and excretion of the drug