Twelve Month Safety and Efficacy Study of CVT-301 In Parkinson's Disease Patients With OFF Episodes

Exclusion Criteria

• •Pregnant or lactating females;
• •Previous surgery for PD or plan to have stereotactic surgery during the study period. Patients who have had deep brain stimulation \[DBS\] will also be excluded unless the procedure was performed more than 6 months prior to study enrollment.
• •History of psychotic symptoms requiring treatment, or suicide ideation or attempt within last year;
• •Known contraindication to the use of levodopa;
• •Any significant condition, severe concurrent disease, abnormality or finding that would make patients unsuitable or may compromise patient safety;
• •Any any contraindication to performing routine spirometry.