Evaluating Safety, Tolerability, and Efficacy of Autologous MitoCell Transplantation in Subjects With Idiopathic Parkinson's Disease

Exclusion Criteria

• •Atypical or secondary Parkinsonism
• •With neurodegenerative disorders other than PD
• •Unable to receive MRI or PET scanning
• •With any concomitant disorder that would contraindicate coagulation, general anesthesia, or stereotactic neurosurgery
• •Received any other investigational agent within 4 weeks prior to Screening
• •History of intracranial surgeries or implantation of a device for Parkinson's disease 2 years prior to Screening
• •Major surgery within the previous 6 months at Screening
• •Significant cardiovascular disease, including:
• •* New York Heart Association (NYHA) class III or IV congestive heart failure
• •* Uncontrolled hypertension: Blood pressure \>140/90 mmHg
• •* History of serious ventricular arrhythmia
• •Malignancy within 2 years prior to Screening
• •Any diagnosis of autoimmune disease or immune compromised state and requiring systemic steroid or immunosuppressive treatment
• •Any other severe systemic disorder, including history of schizophrenia or other psychotic disorders, stroke, seizure, traumatic brain injury, or central nervous system infection, which judged by the investigator that entering the trial may be detrimental to the subject
• •Psychiatric, addictive or any other disorder that compromises ability to give a truly informed consent and perform all study assessments
• •Positive in any of the following regulatory authority-licensed screening tests:
• •* HIV antigen/antibody combo test
• •* Anti-HCV test
• •* Hepatitis B surface antigen (HBsAg) test
• •* Rapid plasma reagin (RPR) test
• •* HIV-1 nucleic acid test (NAT)
• •* HBV NAT
• •* HCV NAT
• •Any of the following hematologic abnormalities:
• •* Hemoglobin \< 9.0 g/dL,
• •* ANC \< 1,500/μL
• •* Platelets \< 100,000/μL
• •Any of the following serum biochemistry abnormalities:
• •* Total bilirubin \> 1.5 × ULN
• •* AST or ALT \> 2.5 × ULN
• •* r-GT \> 2.5 × ULN
• •* ALP \> 2.5 × ULN
• •* serum albumin \< 3.0 g/dL
• •* creatinine \> 1.5 × ULN
• •Female subject who is lactating or has positive serum or urine pregnancy test at Screening Visit
• •Female subject with childbearing potential or male subject with female spouse/partner with childbearing potential who refuses to adopt at least two forms of birth control (at least one of which must be a barrier method) from Screening until Final/Early Termination Visit. Acceptable forms include:
• •* Established use of oral, injected or implanted hormonal methods of contraception
• •* Placement of an intrauterine device (IUD) or intrauterine system (IUS)
• •* Barrier methods of contraception: condom, or occlusive cap (diaphragm or cervical/vault caps)
• •With any condition judged by the investigator that entering the trial may be detrimental to the subject