The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With Fibrosis

Exclusion Criteria

• •Alcohol intake of more than 40gm / week with features suggestive chronic liver disease .
• •Other known cause of chronic liver disease like Hepatitis B,C, autoimmune liver disease, Wilson's disease, alpha 1 antitrypsin deficiency and hemochromatosis, primary biliary cirrhosis, PSC (Primary Sclerosis Cholangitis).
• •Patient on Medication like estrogens, amiodarone, MTx, tamoxifen, ATT (Antitubercular Treatment)
• •Pregnancy or lactation
• •Hypersensitivity to methylxanthines (e.g., caffeine, theophylline,)
• •Recent retinal/cerebral hemorrhage
• •Acute myocardial infarction or severe cardiac arrhythmias.
• •Impaired renal function.