Identification of Liver Fibrosis Biomarkers

Exclusion Criteria

• •Vulnerable person: person deprived of liberty by a judicial or administrative decision and/or person under psychiatric care
• •Self-reported pregnancy or lactating females
• •Disease related to other etiologies, including alcoholic liver disease (alcoholic steatohepatitis), MetALD, specific etiology SLD (e.g. DILI or monogenic disease), cryptogenic SLD, viral hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, human immunodeficiency virus, Wilson's disease, Hemochromatosis, alpha-1 antitrypsin deficiency
• •Any type of carcinoma, unless it is at least 5 years in remission
• •Prior liver transplant
• •Evidence of any other unstable or, untreated clinically significant immunological, neoplastic, endocrine, haematological, gastrointestinal, neurological or psychiatric disorder. Medically controlled comorbidities can be allowed
• •Self-reported alcohol consumption greater 30 g/day (males) 20 g/day (females)
• •Recent myocardial infarction (within last 6 months)
• •Inability to have a liver biopsy, or provide blood sample in a fasted status
• •F0-F2 recalled patients with +/- 5% change in weight between the biopsy and study inclusion