Inclusion Criteria:
Detroit VA Patients with major depression, mild to moderate treated with an SSRI and not having complete remission of symptoms as defined by "feeling their normal selves"
Randomized into two groups:
Experimental: will receive month supply of deplin 15mg, L-tyrosine 6g/d into 2 divided doses, and L-tryptophan 2g/d into 2 divided doses.
Control: will receive month supply of deplin 15mg , and 2 placebo pills.
Beck Depression Scale (BDI-2) to be administered at baseline and every 2 weeks for 1 month.
