Lead Sponsor

InCor Heart Institute

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•Hypertension treated with at least 2 antihypertensive drugs;
•Heart failure with a normal LV ejection fraction;
•Left Ventricular Hypertrophy (LV mass index \> 96 g/m2 in women and \> 116 g/m2 in men);
•≥ 18 years of age;

•Known secondary cause of hypertension
•Uncontrolled blood pressure (≥ 180x110mmHg)
•Unsuitable anatomy of renal arteries, renal stenosis or previous treatment with balloon or stent
•Advanced renal insufficiency (estimated glomerular filtration rate (GFR) \< 30 ml/min/1.73 square meters)
•Diabetes Mellitus type 1
•Acute coronary syndrome or a cerebrovascular accident in the last 6 months
•Known other cause of respiratory dysfunction
•Previous LV systolic dysfunction (LVEF \< 50%)
•Restrictive cardiomyopathy or Hypertrophic cardiomyopathy
•Significant valvar dysfunction
•Atrial flutter or atrial fibrillation
•Use of the oral anticoagulants
•Drug and Alcohol dependence