Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects

Exclusion Criteria

• •Clinically significant medical illness or physical exam findings
• •Active dermatological conditions or skin trauma on the non-dominant hand, or peripheral vascular disease
• •Partial blindness, keratoconus, nystagmus or any other ophthalmic condition which could interfere with pupillometry
• •Use of tobacco or nicotine within 6 months prior to screening
• •History of recent (within 6 months) drug or alcohol abuse, as defined in DSM-IV-TR