Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National University Hospital, Singapore
Age
21–64
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Males and females between 21-65 years of age
Poorly controlled severe persistent asthma (ACT score \< 20) despite high-dose inhaled steroids (\>500 mcg fluticasone/day or \>800 mcg budesonide/day) in combination with inhaled long-acting Beta-2 agonist and/or anticholinergic agent. Other drugs include leukotriene modifiers, omalizumab (if used for at least 1 year prior), and oral corticosteroids 10mg/day or less
Stopped smoking for \> 1 year and \<10 pack-years
Stable maintenance asthma medications for 4 weeks
Pre-bronchodilator FEV1 \>60% predicted
You may not be if
Males and females \<21 and \>65 years of age
Presence of pacemaker, internal defibrillator, or other implantable electronic devices
Known sensitivity to medications required to perform bronchoscopy, including lignocaine and benzodiazepines
Patients previously treated with Bronchial Thermoplasty (BT)
Use of immunosuppressant (excluding oral steroids)
Increased risk of adverse events associated with bronchoscopy or anesthesia (including pregnancy, uncontrolled coronary artery disease, acute or chronic renal failure, and uncontrolled hypertension)
Inability to cease antiplatelet or anticoagulant therapy prior to procedure
Clareo Health | Bronchial Thermoplasty: Mechanism of Action and Defining Asthma Phenotype
