Aldosterone, Microvascular Function and Salt-sensitivity

Exclusion Criteria

• •Obese/lean individuals
• •Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, congestive heart failure, cardiac shunts, cardiac surgery, pulmonary hypertension, cardiac arrhythmias, family history of cardiac arrhythmias or sudden cardiac death)
• •Diabetes mellitus/impaired glucose metabolism (fasting glucose values \> 5.6 mmol/L
• •Stage 3 hypertension (blood pressure \> 180/110 mm Hg)
• •Unstable or severe pulmonary disease
• •Unstable or severe thyroid disorders
• •Inflammatory diseases
• •Smoking
• •Alcohol use \> 2 U/day (women)/\> 3 U/day (men)
• •Use of antihypertensive, lipid-lowering or glucose-lowering medications
• •Use of corticosteroids and regular use of NSAIDs
• •eGFR\< 60 mL/min
• •Impairment of hepatic function
• •Pregnancy or lactation