Lead Sponsor

Midwestern University

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Eligible patients are male or female adults ≥18 years of age with an expected hospital stay of at least 48 hours.
•Eligible patients are already prescribed intravenous vancomycin or linezolid per their primary care providers as a standard of care and dosed in manner that is consistent with current institutional practices. Receipt of these antibiotics is not investigational.

•Additionally, patients will be excluded if they are to receive more than 1 concurrent nephrotoxic medication within the prior 72 hours, have received intravenous contrast within 120 hours before randomization, exhibit baseline hematuria, or baseline proteinuria.
•A list of concurrent nephrotoxins that would exclude patients from the study is provided in Appendix C.
•Age Range: ≥18 years of age, if age \> 90 will report as \> 90 years