Quantitative and Functional Study of TH17 Lymphocytes in Horton's Disease (HD)

Inclusion Criteria

• •Patients
• •Patients who have provided written informed consent
• •Patients with national health insurance cover
• •Age: 50 to 90 years
• •Patients with Horton' s disease :
• •at the diagnosis, before any treatment
• •or in remission
• •or in relapse
• •Patients with an infectious disease :
• •Bacteriologically or radiologically confirmed
• •Presenting an inflammatory syndrome defined by :
• •CRP ≥ 10 mg / L
• •and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1
• •Patients with neoplasia ( solid tumour or hemopathy ) :
• •At the diagnosis, before treatment by chemotherapy
• •Presenting an inflammatory syndrome defined by:
• •CRP ≥ 10 mg / L
• •and Fibrinogen ≥ 4 g / L or ESR ≥ 30 mm at H1
• •Controls :
• •These are healthy volunteers recruited among blood donators at Dijon CHU, voluntary hospital personnel ( nurses, doctors and secretaries ), patients at the EPHAD ( Champmaillot centre for geriatric patients ) and patients without infectious, inflammatory, or auto-immune disease ( CRP \< 5mg / L ) or cancer recruited from the investigating departments of Dijon CHU. They will be matched for age and sex.
• •Age: 18 - 90 years
• •Patients with national health insurance cover
• •who have provided written informed consent
• •Absence of an inflammatory syndrome ( CRP \< 5 mg / L )