Lead Sponsor

Oregon Health and Science University

Age

30 - 60 years

Sex

ALL

Healthy Volunteers

No

•1. Males and females ages 30-60 years of age
•2. Overweight and Obese (28\< BMI \<45)
•3. Confirmed pre-diabetic (5.7≤ HbA1c \< 6.5)
•4. Type 2 DM, Diagnosis 2 years or less, on no medications or metformin only, HbA1c ≤ 6.7

•1. Stage 3 chronic kidney disease (glomerular filtration rate \[GFR\] \< 60)
•2. Obstructive Coronary artery disease
•3. Congestive heart failure (ejection fraction \< 55%)
•4. Peripheral vascular disease,
•5. Degenerative joint disease, musculoskeletal disease, or peripheral vascular disease that limits ability to exercise
•6. Know hypersensitivity to Definity® ultrasound contrast agent
•7. Intra-cardiac or pulmonary shunt
•8. The use of antithrombotic agents or a severe bleeding diathesis due to risk of bleeding with intravenous and arterial line placement
•9. Physical activity greater than three hours per week
•10. Pregnancy

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