Efficacy and Safety of FTY720 for Acute Stroke

Exclusion Criteria

• •Patients who will undergo surgical evacuation of intracerebral hemorrhage
• •Inability to undergo neuroimaging with Magnetic Resonance
• •Glasgow Coma Score \< 6.
• •Baseline modified Rankin Scale score \>1
• •Primary intraventricular hemorrhage ICH due to coagulopathy (PT \> 15 s or International Normalized Ratio \> 1.3, Partial Thromboplastin Time \> 36) or trauma
• •Thrombocytopenia: platelet count \<100 000
• •Clinically significant hepatic disease as demonstrated by history, clinical exam (ascites, varices), or laboratory findings (LFTs \>2x normal, coagulopathy as described)
• •Comorbid conditions likely to complicate therapy including but not limited to the following: a history of New York Heart Association class II, III, or IV Congestive Heart Failure; end-stage acquired immune deficiency syndrome
• •Pregnancy
• •Malignancy (history of or active)
• •Bradyarrhythmia and Atrioventricular Block
• •Concomitant use with antineoplastic,immunosuppressive or immune modulating therapies
• •Macular Edema