Average pain over the past 24 hours of 4 or greater on a 0-10 scale.

Peripheral sensory neuropathy grade 2 or higher.

Personal history of schizophrenia or major depressive disorder, or history of suicidal ideation or attempt within the past 2 years.

Thumbnail abnormalities on either hand (such as artificial nails) that are likely to alter pain perception during testing.

Pregnant or nursing.

No prior chemotherapy for any reason

Effect of Chemotherapy on Pain Sensitivity and Patient-reported Symptoms