Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Wonju Severance Christian Hospital
With
Pfizer
Age
20–79
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients aged 20 years or older and below 80 years.
Patients who have not previously taken any antihypertensive drugs or have discontinued previous antihypertensive drugs for 2 weeks.
Mean SBP ≥140 mmHg or mean diastolic BP ≥ 90 mmHg (blood pressure will be checked at least 2 times in a seated position during the screening period).
You may not be if
Pregnant women, possible candidate for pregnancy, or breastfeeding women.
Known or suspected secondary hypertension.
Mean seated SBP ≥ 180 mmHg and/or mean seated diastolic BP ≥ 120 mmHg at any visit.
Any clinically significant hepatic impairments.
Severe renal impairment (serum creatinine level \> 3.0 mg/dL or creatinine clearance \< 30 mL/min).
Bilateral renal artery stenosis, renal artery stenosis in a solitary kidney, or post-renal transplant.
Clinically relevant hyperkalemia.
Uncorrected volume or sodium depletion.
Suspected primary aldosteronism.
1. Hypertension and spontaneous or low-dose diuretic-induced hypokalemia.
2. Drug-resistant hypertension, defined as sub-optimally controlled hypertension on a 3-drug program that includes an adrenergic inhibitor, vasodilator, and diuretic.
3. Hypertension with adrenal incidentaloma.
4. Hypertension and a family history of early-onset hypertension or cerebrovascular accident at a young age (\<40 years).
5. Hypertensive first-degree relatives of patients with primary aldosteronism.
Symptomatic congestive heart failure.
Angina pectoris requiring treatment.
History of myocardial infarction or cerebrovascular accident (ischemic stroke or hemorrhage).
History of refractory or potentially lethal arrhythmias.
Concurrent participation in another clinical trial.
Patients with known intolerance, contraindication, or hypersensitivity to any component of dihydropyridines or angiotensin II receptor blockers.
Patients who are deemed unsuitable by the investigator.
