Loading clinical trials...
Loading clinical trials...
Diabetes is more likely to occur during pregnancy. When present only in pregnancy it is called gestational diabetes, and it places both mom and baby at risk for complications. Glyburide is one of the currently used treatments for diabetes during pregnancy. This drug is a medication taken by mouth that decreases sugar levels in the blood. It is known to decrease the risk of complications linked to diabetes in pregnancy. Recent studies in pregnancy have described a difference in the way and how well the drug works compared to when used outside of pregnancy. Oral blood sugar lowering agents are approved by the Food and Drug Administration (FDA) to lower blood sugar in non-pregnant subjects with diabetes. No oral (taken by mouth) blood-sugar lowering agents are FDA approved for use in pregnancy. Although Glyburide is not FDA approved for this use, it is the most commonly used oral blood sugar lowering agent in pregnancy. This research study will help us learn more about the variations in blood sugar levels in women with diabetes in pregnancy who are taking glyburide and how changes in the timing of when the glyburide is taken would affect blood glucose levels. The goals of this study are: * To find the how glucose changes throughout the day in women with diabetes in pregnancy receiving glyburide * To learn the effect of changing the time of taking glyburide on glucose levels * To learn the effect of changing the time between glyburide doses on glucose levels * To see if insulin is secreted the same throughout the day in response to a morning dose of glyburide.
Age
18 - 50 years
Sex
FEMALE
Healthy Volunteers
No
Magee Womens Hospital of UPMC
Pittsburgh, Pennsylvania, United States
Start Date
September 1, 2013
Primary Completion Date
September 1, 2014
Completion Date
September 1, 2014
Last Updated
May 11, 2016
Glyburide
DRUG
Continuous glucose monitor
DEVICE
Lead Sponsor
University of Pittsburgh
NCT06648174
NCT06948825
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and Conditions