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Endophenotypes of Dementia Associated With Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI) among residents of the Armed Forces Retirement Home, Washington D.C. and the Veterans Home of California-Yountville. Investigators will compare the characteristics of dementia in those who have had a prior TBI to the characteristics in those without a history of TBI. It is our hypothesis that the dementia or MCI among those with prior TBI has distinct neuropsychological features that distinguishes it from those with dementia or MCI without a history of TBI.
75 participants with a history of TBI will be the cases (exposed) group. A control group of 75 retirement home residents without a history of TBI who are age-matched to the cases will also be recruited. Participants will be evaluated in a single visit, which will include neurological, psychiatric, and cognitive assessment. The evaluation will take approximately 4 hours. In some cases, the evaluation may be split into two 2 hour sessions.
Age
50 - 95 years
Sex
ALL
Healthy Volunteers
Yes
California Veterans Home-Yountville
Yountville, California, United States
Armed Forces Retirement Home
Washington D.C., District of Columbia, United States
Start Date
July 1, 2013
Primary Completion Date
June 1, 2016
Completion Date
August 1, 2016
Last Updated
January 18, 2019
Lead Sponsor
Uniformed Services University of the Health Sciences
Collaborators
NCT04246437
NCT06780917
Data Source & Attribution
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