TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients

Exclusion Criteria

• •Unable to follow simple commands at baseline
• •Pregnancy
• •Acute conditions impairing ability to walk or cycle (e.g., leg or foot fracture)
• •Acute central condition or peripheral injury resulting in neuromuscular weakness (e.g., stroke, Guillain Barré syndrome)
• •Primary generalized weakness of the central or peripheral nervous system (e.g., multiple sclerosis, myasthenia gravis, Parkinson's disease, amyotrophic lateral sclerosis)
• •Temporary pacemaker wires
• •Expected hospital mortality\> 90%
• •Cycling equipment unable to fit patient's body dimensions (e.g., leg amputation or obesity)
• •Specific surgical exclusion as stipulated by attending
• •-\>7 day ICU stay
• •Physician declines
• •Patient did not meet daily screening criteria to provide in-bed leg cycling during the first 4 days of mechanical ventilation