Lead Sponsor

Astute Medical, Inc.

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

No

•Males and females 21 years of age or older
•Receiving care in an intensive care unit
•Expected to remain in the ICU for at least 48 hours after enrollment
•Use of indwelling urinary catheter as standard care at the time of enrollment
•Subject must have acute kidney injury (KDIGO stage 2 or stage 3) at the time of the first sample collection
•First sample must be collected within 36 hours of meeting KDIGO stage 2 criteria
•Written informed consent provided by patient or legally authorized representative (LAR)

•Prior kidney transplantation
•Comfort-measures-only status
•Already receiving dialysis (either acute or chronic) or in imminent need of dialysis at the time of enrollment
•History of human immunodeficiency virus (HIV) or hepatitis virus (based upon available medical records) infections (NOTE: HIV or hepatitis testing need not be performed for enrollment in this study.)
•Special populations, pregnant women, prisoners or institutionalized individuals
•Patient meets any of the following:
•* Active bleeding with an anticipated need for \> 4 units PRBC in a day
•* Hemoglobin \< 7 g/dL
•* Any other condition that in the physician's opinion would contraindicate drawing serial blood samples for clinical study purposes