Comparison of Immunogenicity and Safety of Inactivated and Live Attenuated Hepatitis A Vaccines in Young Adults

Exclusion Criteria

• •Axillary temperature \> 37.0 centigrade at the time of dosing
• •Subject that has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine
• •Serious adverse reactions to vaccines such as anaphylaxis, hives, respiratory difficulty, angioedema, or abdominal pain
• •Autoimmune disease or immunodeficiency
• •Congenital malformation, developmental disorders or serious chronic diseases (such as Down's syndrome, diabetes, sickle cell anemia or neurological disorders)
• •Bleeding disorder diagnosed by a doctor (e.g. factor deficiency, coagulopathy, or platelet disorder requiring special precautions) or significant bruising or bleeding difficulties with IM injections or blood draws
• •History or family history of convulsions, epilepsy, brain disease and psychiatric
• •History of any blood products within 3 months
• •Administration of any other investigational research agents within 30 days
• •Administration of any live attenuated vaccine within 30 days
• •Administration of subunit or inactivated vaccines within 14 days
• •Any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer's ability to give informed consent
• •anti-HBsAg positive
• •anti-HAV positive
• •Pregnancy test result is positive