Magnetic Resonance & Optical Spectroscopy Validation

Exclusion Criteria

• •Have internal metal medical devices, including cardiac pacemakers, aortic or cerebral aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire sutures, joint replacements, bone or joint pins/rods/screws, metal fragments in your eye, or non-removable jewelry such as rings.
• •Are unwilling or unable to complete the imaging procedures for the duration of the magnetic resonance imaging (MRI) scan due to claustrophobia or other reason.
• •Serious mental illness that might preclude subject's ability to comply with study treatment
• •Are pregnant or plan on becoming pregnant in the next 8 weeks.
• •History of deep vein thrombosis (DVT) or pulmonary embolism (PE)
• •Varicose Veins
• •Known genetic factor (Factor V Leiden, etc.) or hypercoagulable state, including cancer, leukemia - such as chronic myelocytic leukemia (CML), hemoglobinopathies - such as sickle-cell disease and multiple myeloma and other proteinopathies.
• •Diagnosed peripheral arterial or vascular disease
• •Family history of primary DVT or PE
• •Peripheral neuropathy
• •History of chronic venous stasis or lower extremity edema
• •Female taking hormonal birth control (oral or otherwise) AND smoker