Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer

Exclusion Criteria

• •Previous bowel resection which, in the opinion of the investigator, would decrease the benefit of the probiotic. Patients who have undergone recent bowel surgeries which would not decrease the benefit of the probiotic are eligible provided they are more than 30 days from surgery with no serious complications.
• •Known allergy to a probiotic preparation.
• •Any history of inflammatory bowel disease.
• •Grade 3 or 4 diarrhea, rectal bleeding, abdominal cramping, or incontinence of stool ≤7 days prior to registration.
• •Any medical condition that may interfere with ability to receive protocol treatment.
• •Prior abdominal or pelvic RT.
• •Use of probiotics ≤ 2 weeks prior to registration.
• •Use of antibiotics ≤ 3 days prior to registration.
• •Planned continuous antibiotic treatment during RT.
• •History of gastrointestinal or genitourinary obstruction or porphyria.
• •History of irritable bowel syndrome (IBS).
• •History of hypersensitivity to all of the following antibiotics: penicillin, erythromycin, clindamycin, and any fluoroquinolone.