CRC Detection Reliable Assessment With Blood

Exclusion Criteria

• •3. Participant is able and willing to undergo a screening colonoscopy
• •4. Participant is able and willing to sign informed consent and adhere to study requirements
• •5. Participant is able to provide blood sample prior to colonoscopy (within 90 days of scheduled colonoscopy).
• •1. Previous personal history of CRC or precancerous lesions
• •2. Positive result from non-invasive screening test within the associated recommended intervals:
• •2.1 Fecal occult blood test or fecal immunochemical test within the previous 12 months 2.2 Epi proColon test within the previous 12 months 2.3 FIT-DNA (Cologuard) test within the previous 36 months
• •3. Diagnosed with condition associated with higher risk for colorectal cancer, such as:
• •3.1 Inflammatory bowel disease (IBD) 3.2 Chronic ulcerative colitis (CUC) 3.3 Crohn's disease 3.4 Familial adenomatous polyposis (FAP) 3.5 Familial history for colorectal cancer 3.5.1 One or more first-degree relatives diagnosed with CRC or adenomatous polyps before 60 years of age 3.5.2 Two or more first degree relatives diagnosed at any age with CRC
• •4. Individuals with relevant familial (hereditary) cancer syndrome, such as:
• •4.1 Hereditary non-polyposis colorectal cancer syndrome (HNPCC or Lynch Syndrome) 4.2 Peutz-Jeghers Syndrome 4.3 MYH-Associated Polyposis (MAP) 4.4 Gardner's syndrome 4.5Turcot's (or Crail's) syndrome 4.6 Cowden's syndrome, 4.7Juvenile Polyposis 4.8 Cronkhite-Canada syndrome 4.9 Neurofibromatosis 4.10 Familial Hyperplastic Polyposis
• •5. Diagnosed with chronic gastritis or cirrhosis
• •6. Current diagnosis of any cancer, except non-melanoma skin cancer
• •7. Overt rectal bleeding or bleeding hemorrhoids within previous 30 days
• •8. A colonoscopy within the previous 9 years, with the exception of a failed colonoscopy due to poor bowel preparation
• •9. Pregnancy