The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)

Exclusion Criteria

• •For skin and adipose biopsy, any subject with known bleeding disorder, current fever or on anticoagulation.
• •Pregnant women and lactating women, may not undergo any study procedures until they are no longer pregnant or breast feeding.
• •Subjects with a contraindication to MRI scanning will not receive the optional PET/MRI. These contraindications include subjects with the following devices:
• •* Central nervous system aneurysm clips
• •* Implanted neural stimulator
• •* Implanted cardiac pacemaker or defibrillator
• •* Cochlear implant
• •* Ocular foreign body (e.g. metal shavings)
• •* Implanted Insulin pump
• •* Metal shrapnel or bullet
• •Subjects with a BMI \>45 will also not receive the PET MRI.
• •Subjects with severe renal excretory dysfunction, estimated glomerular filtration rate \< 30 mL/min/1.73m\^2 body surface area according to the Modification of Diet in Renal Disease criteria, will not receive the cardiac CT angiography, or gadolinium contrast agent during the PET/MRI.