Effect of Hepatic Impairment on LDE225..

Inclusion Criteria

• •Male and sterile or postmenopausal female age ≥18 to ≤70 years old.
• •Normal Vital signs
• •Inclusion (group mild, moderate and severe hepatic impairment):
• •Subjects with confirmed cirrhosis
• •Exclusion (all groups):
• •Woman of childbearing potential and pregnant or lactating females or male not using condom
• •Risk factors for torsades de pointes
• •Clinically significant cardio-vascular disease
• •severe or uncontrolled medical conditions
• •Smokers consuming greater than 10 cigarettes or equivalent nicotine containing products per day.
• •Use of investigational drugs (i.e. participation in any clinical investigation)
• •Exclusion for moderate, mild and severe groups:
• •Symptoms or history of encephalopathy
• •Clinical evidence of severe ascites