Evaluating Patients With Impaired Hepatic Function

Inclusion Criteria

• •1. Has histologically or cytologically proven advanced solid tumors for which no standard therapy exists.
• •2. Has provided written informed consent.
• •3. Is 18 years of age or older.
• •4. Is able to take medications orally.
• •5. Has Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to ≤ 2 (Appendix A, ECOG Performance Status).
• •6. Has adequate organ function as defined by the following criteria:
• •1. Absolute granulocyte count ≥ 1,500/mm3 (ie, ≥ 1.5 x 109/L by International Units \[IU\]).
• •2. Has a platelet count ≥ 100,000/mm3 (IU: ≥ 100 x 109/L).
• •3. Has a hemoglobin value of ≥ 9.0 g/dL.
• •4. Has a calculated creatinine clearance \> 60 mL/min (by Cockcroft-Gault
• +23 more criteria