The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'

Inclusion Criteria

• •Older HIV-positive cohort (n=1000):
• •documented HIV infection
• •age \>50 years at study entry
• •self defined white or black African ethnicity
• •likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African
• •able to comprehend study patient information leaflet
• •-Younger HIV-positive cohort (n=500):
• •documented HIV infection
• •age \<50 at study entry\*
• •self defined white or black African ethnicity
• •likely route of HIV acquisition via sexual exposure Either by male to male exposure if white or by heterosexual exposure if white or black African.
• •able to comprehend study patient information leaflet
• •* this group will comprise of at least 150 subjects in each of the following age groups: 20-29, 30-39, 40-49 years. Recruitment will be monitored by the Study Monitoring Team.
• •HIV-negative cohort (n=500):
• •documented negative HIV test at screening
• •age \>50 years at study entry
• •self defined white or black African ethnicity
• •registered with a General Practitioner and gives permission for contact with that General Practitioner.