L-serine and Strength Training in the Elderly

The study is a randomized, controlled, double-blind intervention study with three parallel groups of healthy older adults (aged 65-85). It investigates the effects of L-serine supplementation with and without accompanying strength training on cognitive, neural, molecular, and functional parameters over 48 weeks. The primary endpoint is the change in cognitive performance, measured using the composite RBANS score. Secondary endpoints include structural and functional brain parameters (MRI, EEG), psychosocial parameters, markers of oxidative stress and immune function, as well as physical performance and muscle mass.