Response to Influenza Vaccine in Patients With Non-Hematologic Malignancies Receiving Chemotherapy

Exclusion Criteria

• •Patients who have already received the influenza vaccine during the season in which they are considered for eligibility will be excluded
• •History of allergic reactions attributed to compounds of similar chemical or biologic composition to the influenza vaccine or egg allergies
• •Previous history of Guillian-Barre syndrome within the previous 6 weeks to influenza vaccination
• •Patients must not be receiving chronic steroid therapy, defined as \>= 14 days, unless used as part of a chemotherapy regimen
• •Patients must not be on any other agents that can suppress the immune system
• •Planned concurrent therapy with radiation
• •Uncontrolled illness at time of enrollment or influenza vaccination including, but not limited to, ongoing or active febrile illness
• •Psychiatric illness/social situations that would limit compliance with study requirements
• •Known immunosuppression eg. history of organ transplantation or known human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because they may not be able to mount an appropriate immune response
• •History of influenza-like illness, defined as a temperature \> 37.8 degree C with cough or sore throat starting October 1, 2011 throughout the duration of the study
• •Patient may not be scheduled to receive chemotherapy on a weekly basis.